Despair is Chapter 4 of The House of the Dead 4.
In a flashback from the past, Goldman tells the player about the evils of the human race, such as their greed which is harming the planet.
After finding a way out from the railroad, Kate asks James if hope still exists, which he says that it does and there's no turning back now. As they find an underground shopping district, they are welcomed by a group of zombies. They fight their way through new breeds of zombies including flying ones to the surface and find that it has been destroyed. As they try to find their way through, they are greeted by a very large foot and meet Temperance. The two try to fight it, but find that their bullets are not hurting it at all. After finding a clock tower, they decide to use the clock against Temperance. After fighting through several groups of undead who had taken residence in the tower, they reach the clock and loosen it from the tower, falling on Temperance and cracking it's skull, killing it.
They later reach the top of the tower to see what has happened to the city, only to find that it has been overrun completely. James then gets a message on his PDA; it's from Goldman!
You are greeted with a group of zombies climbing over some turnstiles. After they're defeated, a group of zombies will burst open from a doorway before you proceed further, when a mannequin is thrown but misses you. You will turn around and find three Ottos were responsible for throwing at you; shred them before they hit you. As you go further, you will see zombies attempting to open a partially closed gate and you will need to turn the lever to close it. If you don't close it in time, the zombies will manage to open the gate and must be fought. Afterwards, a flying zombie will break from the ceiling above and attempt to attack you.
You will go further and find more zombies including an Otto attempting to hold up a gate. If you kill the Otto, the gate will hold and will not collapse, but will result in a bit more zombie reinforcements. Afterwards, you will enter a shop Kate "loves". Zombies will burst out from a door and some will appear from behind the shelves. You will turn to your right where three Kageo torsos are hiding under the tables and will attempt to claw you. Kill them and you will turn to find a door; shoot it to find a grenade and three point boosters before you leave. As you leave the shop, two Shanes will pop up from behind the counter and attempt to throw their axes at you. Zombies break through the windows after they are killed in two separate groups. After leaving the shop for good, more zombies appear from a hidden path.
If you left the Otto alone, the gate will collapse and block incoming reinforcements. You will be redirected to another shop instead, where you look at a shelf which two Ottos will push, accompanied by two axe-wielding Shanes. Three more zombies will appear after they die and as you leave, a door will open with an Otto attempting to open it. If you don't push it back in time, the door will open and result in a few more reinforcements to be dealt with before you leave. After leaving the shop, you will see zombies banging on the windows on the shop Kate "loves" and will manage to break it. Two groups of zombies are dealt with immediately so a grenade might be recommended to clear some out.
Regardless of your decision, two flying zombies will be waiting at the exit to the surface. Clear them out. When you reach the surface, several zombies will jump at your location; they aren't much of a threat but a grenade might be recommended for the inexperienced. After they are defeated, you will turn to your right where more zombies are waiting for you. There is a small school bus running around the second group, so shoot it if you can for extra points. You will then look up to find three flying zombies; kill them to start the boss fight.
++++++++++++++++++++++++++++++++++++++++++++++++++ + [ Temperance (Type 0483) ] + + WEAK POINT: The head + + NO DAMAGE: Anywhere else + ++++++++++++++++++++++++++++++++++++++++++++++++++
Temperance simply attempts to stomp you by walking closer to you. Shoot his head quickly, although his obese body may sometimes cover his head while he walks towards you. After just three steps, Temperance will get ready to jump, squishing you with his feet. Once the CANCEL bar is filled, Temperance will stumble a bit, unfazed by your attacks.
This phase is similar to phase 1; Temperance simply attempts to stomp you by walking closer to you. Shoot his head quickly, although his obese body may sometimes cover his head while he walks towards you. Once the CANCEL bar is filled, Temperance will stumble a bit, unfazed by your attacks.
Temperance realizes that just attempting to stomp you won't work anymore. Temperance will roll up into a ball and attempt to run you over with his body. Shoot his head quickly; after three rolls the next roll is guaranteed to squish you for sure. Once the CANCEL bar is filled, Temperance will stumble and fall over.
Temperance decides to be creative and uses the same attack just as in the last phase. However, he starts backwards instead, so his head may be harder to shoot. Shoot his body while he curls up into a ball, and send quick bursts at his head whenever visible before he rolls you over. Once the CANCEL bar is filled, Temperance will stumble and fall over.
After deciding that the clock may be the only way to kill Temperance, the pair will run into the clock tower. You are greeted with a mob of zombies at the door, so clear them out quickly. As you find the staircases, more zombies appear from the side and the staircase; clear them out before you will go up.
Temperance knows you're inside the tower, and will peer through the openings of the building. Shoot his head whenever it is visible. After Temperance looks in three times, he'll send his fist flying through the building, hitting you. He will do this twice during this phase. When the CANCEL bar is filled, Temperance will stumble and fall onto the ground.
As you reach the floor with the clock, another group of zombies greets you. After the group is taken out, two flying zombies will run in, so kill them quickly before they get a bite out of you. There is an explosive barrel to deal with them, although experienced players will not need to shoot it.
As you reach the clock mechanism, Temperance runs in to greet you. James will say that you need to move the lever regardless of what happens. A Quick Time Event will occur and you must shake the clock free. If you don't, Temperance's eyes will glow red and he'll take a bite out of you before you will send the clock on him. If you manage to shake the mechanism in time, he will not have the chance to bite you.