Despair is the fourth chapter of The House of the Dead 4.
In Goldman's flashback of three years ago, Goldman questioned about the increase of wars and famines, diseases of unknown origin, and increasingly frequent natural disasters. He ends his statements with the question: "Must we simply sit and wait for it all to end?"
Back in the present, after their battle with the Empress, Kate asks the survivors' whereabouts, with James hoping they all managed to evacuate and that there is no turning back. James eventually busts a steel door open, leading to the subway's exit, only to be greeted by hordes of undead throughout. They managed to reach the surface, only to be spotted by more undead as the Temperance begins his attack. They manage to defeat him by throwing a clock to his body from atop the clock tower, as they continue to the roof to see the entire city and, much to their shock...they find that city is in ruins!