Two weeks after her father went missing from a mission, the 19-year old made a promise to her mother that she would find him and bring him back home. Asking his former AMS colleague G for help, the two of them arrived at the zombie-infested research center where contact with him was lost.
Throughout the story, she is shown to have a somewhat tense relationship with her father, since he was always on missions. This is especially emphasized when she says she hardly has any memories of her father spending time with her and her mom (which even G considers "a little harsh") and even going to the point of saying that she should "smack him upside the head for Mom!" Another point she brings up is her father always saying "you've got to believe in yourself" constantly, to the point that she's sick of it.
But despite all this, she does care about her father. For when she finally found him midway the final stage, she was overjoyed to see him safe (thanks to Daniel Curien, the son of Dr. Roy Curien, who supposedly saved him from Death Type 0011) and expressing concern when he wanted to continue the mission even though he was hurt. Shortly after, Daniel agrees to go with Lisa to finish the mission while G looks after Rogan. It's at this time that Rogan once again tells Lisa to believe in herself, this time with Lisa finally understanding what the saying really means.
Together with Daniel, Lisa fights through a horde of zombies before reaching the chamber where Curien's true masterpiece, The Wheel of Fate (who actually is Curien himself undergoing a resurrection process), is being held, and defeats it.
- Lisa uses her shotgun left handed due to her being player one, although she uses it right handed in cutscenes.
- Lisa is the first female playable character to be featured in the main series, the second being Kate Green. This is not counting Linda Rotta, who starred in the spin-off Zombie Revenge, which predated The House of the Dead III.
- Lisa's real middle name is "Richards" (or R.) because her mother is confirming to be a Richard surname like Sophie's name to be changed (Sophie R. Rogan)